Your Fertility Questions, Answered by Dr. Geoffrey Sher (Full Q&A)
If you’ve been navigating fertility treatment and wondering why things aren’t working, this is a conversation you need to hear.
As part of my free monthly fertility support group, I hosted a live Q&A with Dr. Geoffrey Sher, one of the pioneers of IVF in the U.S. Known for his direct, experience-driven approach, Dr. Sher answered real questions submitted by attendees—from IUI and IVF timing to failed implantation, immune testing, egg quality, and more.
Whether you’re preparing for your first cycle or reevaluating after multiple failed transfers, this Q&A offers clarity, real insight, and permission to challenge the standard advice.
Watch the Full Video
Key Takeaways from the Q&A
1. When IUI Works—and When It Doesn’t
IUI is most effective for younger patients with open tubes and no underlying conditions.
It’s often ineffective in cases of endometriosis, diminished ovarian reserve (DOR), or women over 35–40.
“In many cases, IUI doesn’t improve outcomes over doing nothing at all.”
2. Flare Protocol: Why It May Be Harming Egg Quality
Flare protocols can cause a surge in LH, increasing testosterone in the ovaries.
For patients with DOR or over 40, this may lead to poor egg quality and premature luteinization.
“I never use flare protocols in these cases.”
3. What Can Prevent Embryo Implantation
Dr. Sher outlined three common causes:
Thin uterine lining
Uterine abnormalities (polyps, scarring)
Immune dysfunction, such as natural killer cell activation
Endometriosis and autoimmune history are often overlooked as contributors.
4. Fertility Supplements: What Actually Helps
His recommendations: Folic acid, CoQ10, Omega-3, B6, D3, and iron.
He strongly advises against DHEA, especially for women with DOR, due to testosterone conversion.
5. Personalized Protocols Matter
Many failed IVF cycles are due to inappropriate stimulation protocols.
He shared his agonist-antagonist conversion protocol, especially helpful for poor responders.
💬 You can learn more about his approach at sherfertilitysolutions.com.
What I Wish More People Knew…
Every month, I hear from people who are burned out, confused, and starting to blame themselves. Sessions like this remind us: you are not the problem. The standard one-size-fits-all approach to fertility care often fails to account for the complexity of your body—and your history.
Hearing from someone like Dr. Sher, who’s willing to challenge the norm, can be both validating and empowering. I hope this conversation gives you the language to ask better questions and the confidence to keep advocating for yourself.
